ArticleScience advances2026
Ultrasensitive chiral detection by nonlinear chiroptics in spiral plasmonic metastructures surpasses linear limits.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Chiral sensing is vital in pharmaceuticals and biomedicine but is hindered by the inherently weak chiroptic signals of molecules. Conventional methods rely on tedious chromatographic techniques with expensive chiral columns. This work introduces a breakthrough in ultrasensitive chiral detection by combining nonlinear optics and tailored chiral plasmonics. We fabricate spiral gold metastructures that provide strong enhancements of both electric and superchiral near fields, which simultaneously optimize both the nonlinear conversion efficiency and dissymmetry factor, thereby generating a prominent nonlinear chiroptic response to chiral molecules. The resulting change of circularly polarized second-harmonic generation (ΔCP
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