ArticleProceedings of the National Academy of Sciences of the United States of America2026
Neonatal enteric infection disrupts the microbiota-gut-brain axis through pattern recognition receptors and altered neuroimmune signaling.
Abstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Microbial shifts in early life: the pediatric gut microbiome and its role in health and disease.Gut microbes · 2026Review
- Vagus nerve stimulation limits colonic inflammation through distinct neuroimmune circuitry shaped by inflammatory history.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
- Update of
Authors and funding
21 authors.
Jungjae ParkDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.
Olivia OrahoodDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.
Maithili BanginwarDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0009-0007-2859-302X
Amy AndradeDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.
Gatha PoreDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.
Kristina SanchezDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.
Michael CreminDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-1875-7920
Alessandra MillerDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0009-0000-5939-9296
Jelissa Reynoso-GarciaDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.
Sarah LeeDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0009-0009-9654-4662
Eric JungDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.
Jane LiDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.
Nidhi KikkeriDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0009-0000-3117-4634
Ingrid Brust-MascherDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0000-0001-7733-4410
Mariana BarbozaDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-0725-4535
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, CA 95616.ORCID 0000-0001-7190-5323
Taeseon WooDepartment of Molecular Pathobiology, College of Dentistry, Department of Pediatrics, Grossman School of Medicine, New York University, New York, NY 10010.ORCID 0009-0002-1195-0194
Kara G MargolisDepartment of Molecular Pathobiology, College of Dentistry, Department of Pediatrics, Grossman School of Medicine, New York University, New York, NY 10010.
Zarife Nigar Ozdemir KumralDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.
Colin ReardonDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0000-0003-2204-8091
Mélanie G GareauDepartment of Anatomy, Physiology, and Cell Biology, Weill School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0000-0001-6008-6975
Funding
Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9MInterdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8MAnimal Models of Infectious Diseases Training ProgramT32AI060555 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI MCSORLEY, STEPHEN J · 2004 to 2025
$3.3MCoordination of mucosal immune response to enteric bacterial pathogens by nociceptive innervationR01AI150647 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI REARDON, COLIN · 2020 to 2024
$2.4MLearning, Memory, and Plasticity (LaMP) Training ProgramT32MH112507 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Karen Zito · 2017 to 2026
$2.4MThe microbiota-gut-brain axis in Alzheimers diseaseR01AT009365 · NCCIH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GAREAU, MELANIE G · 2017 to 2021
$2.2MLinkage of s100a10 (p11) to enteric 5-HT4-mediated serotonergic signaling roles in GI motility, enteric nervous system development, and co-morbid dysfunction of gut and brainR01DK126644 · NIDDK · NEW YORK UNIVERSITY · PI MARGOLIS, KARA GROSS · 2021 to 2024
$1.9MEarly microbial colonization and development of the microbiota-gut-brain axisR21MH108154 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GAREAU, MELANIE G · 2015 to 2016
$542kNeuroimmune control of lung inflammationR56AI179656 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI REARDON, COLIN · 2024 to 2024
$350kHHS | NIH | National Center for Complementary and Integrative Health (OAM) R01AT009365HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI150647HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32AI060555HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK126644HHS | NIH | National Institute of Mental Health (NIMH) MH112507HHS | NIH | National Institute of Mental Health (NIMH) R21MH108154HHS | NIH | National Institute of Mental Health (NIMH) T32MH073124NCCIH NIH HHS R01 AT009365NCI NIH HHS P30 CA093373NIAID NIH HHS R01 AI150647NIAID NIH HHS R56 AI179656NIAID NIH HHS T32 AI060555NIDDK NIH HHS R01 DK126644NIMH NIH HHS R21 MH108154NIMH NIH HHS T32 MH073124NIMH NIH HHS T32 MH112507
Abstract
Early-life enteric infection disrupts the developing microbiota-gut-brain (MGB) axis. Using a neonatal Enteropathogenic
Indexed as
BrainBrain-Gut AxisEscherichia coli InfectionsGastrointestinal MicrobiomeNeuroimmunomodulationReceptors, Pattern RecognitionAnimalsAnimals, NewbornEnteropathogenic Escherichia coliIntestinal Barrier FunctionIntestinal MucosaMiceMice, KnockoutNod1 Signaling Adaptor ProteinNod2 Signaling Adaptor ProteinSignal TransductionNod1 protein, mouseNod1 Signaling Adaptor ProteinNod2 Signaling Adaptor ProteinReceptors, Pattern Recognitionbacterial infectionenteric neuronsgut-brainneuroimmuneprobiotics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.