ArticleProceedings of the National Academy of Sciences of the United States of America2026
Network topology creates independent control of multiple checkpoints in the cell cycle system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Network topology creates independent control of multiple checkpoints in the cell cycle system.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
In living cells, numerous chemical reactions are interconnected by sharing substrates and products, forming a huge reaction network. The various functions of cells emerge from the dynamics of such interconnected system. Cells regulate the concentrations of key biochemicals by controlling the amount or activity of enzymes that catalyze each reaction, thereby achieving control of cellular functions. However, in such an interconnected system, can different chemicals responsible for different biological functions be controlled independently? If so, by what mechanism? This paper mathematically demonstrates that "modularity," where parts of a system are controlled independently of others, arises solely from network topology. Furthermore, using the cell cycle system as an example, we show through a combination of theory and experiments that such "regulatory modules" actually exist in living organisms, performing important roles. In the cell cycle, the G
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