Comparison of the Utility of Amplitude-Spectral and Coherence Features of Psychotropic Drugs' Action on ECoG Signal for Pharmaco-EEG Based Drug Screening in Rats.

Yuriy I Sysoev, Nikita S Kurmazov, Darya D Shitc, Sergey V Okovityi

Abstract read

In one paragraph

Article in Methods and protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Yuriy I SysoevLaboratory of Motor and Visceral Functions Neuromodulation, Pavlov Institute of Physiology, Russian Academy of Sciences (RAS), 199034 Saint-Petersburg, Russia.ORCID 0000-0003-4199-5318

Nikita S KurmazovDepartment of Pharmacology and Clinical Pharmacology, Saint-Petersburg State Chemical Pharmaceutical University, 197022 Saint Petersburg, Russia.ORCID 0000-0001-7212-6903

Darya D ShitcInstitute of Translational Biomedicine, Saint Petersburg State University, 199034 Saint Petersburg, Russia.

Sergey V OkovityiDepartment of Pharmacology and Clinical Pharmacology, Saint-Petersburg State Chemical Pharmaceutical University, 197022 Saint Petersburg, Russia.ORCID 0000-0003-4294-5531

Funding

Pavlov Institute of Physiology of the Russian Academy of Sciences 124020100105-6St Petersburg University 125022102790-5

6 · The paper itself

Abstract

A naive Bayesian classifier (NBC) combined with principal component analysis (PCA) effectively differentiates the dose-dependent effects of certain groups of psychoactive drugs based on their impact on the amplitude-spectral characteristics of electrocorticograms (ECoG) in rats. This approach has been shown to be useful for pharmacological screening of agents with unknown or poorly understood activity. Despite previously obtained optimistic results, classification determination for some drugs was inaccurate, necessitating the search for possible ways to improve the predictive effectiveness of the proposed algorithm. One possible approach would be to use as input quantitative data not only the impact of the psychoactive drugs studied on the amplitude-spectral characteristics of ECoG but also connectivity changes, including the average coherence power of different pairs of leads.

Indexed as

amplitude–spectral analysiscoherence analysisECoGnaive Bayesian classifierpharmaco-EEGprincipal component analysisrats

Identifiers

PMID42776676

DOI10.3390/mps9050123

PMCPMC13600116

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.