ArticleNeuroSci2026
Environmental Enrichment Exerts a Selective, Stage-Dependent Modulation on the Autism-like Behavioral Phenotype Induced by Embryonic Valproic Acid in Zebrafish.
Esveidy Roldan-Anzures, Bernardo S Flores-Prieto, Lizbeth A Ortega-Pineda, Jorge Manzo, Genaro A Coria-Avila, Deissy Herrera-Covarrubias, Lauro Fernández-Cañedo, Gonzalo E Aranda-Abreu, Fausto Rojas-Durán, Ernesto Maldonado and 3 more
Abstract read
In one paragraphArticle in NeuroSci, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Esveidy Roldan-AnzuresInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91000, Mexico.
Bernardo S Flores-PrietoFacultad de Psicología (Campus Veracruz), Universidad Veracruzana, Veracruz 91700, Mexico.ORCID 0000-0002-7795-0739 Lizbeth A Ortega-PinedaFacultad de Medicina (Campus Xalapa), Universidad Veracruzana, Xalapa 91000, Mexico.
Genaro A Coria-AvilaInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91000, Mexico.ORCID 0000-0003-1663-836X Deissy Herrera-CovarrubiasInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91000, Mexico.ORCID 0000-0001-5752-4700 Lauro Fernández-CañedoFacultad de Medicina (Campus Xalapa), Universidad Veracruzana, Xalapa 91000, Mexico.
Gonzalo E Aranda-AbreuInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91000, Mexico.ORCID 0000-0001-8519-5473 Fausto Rojas-DuránInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91000, Mexico.ORCID 0000-0003-4497-0909 Ernesto MaldonadoInstituto de Ciencias del Mar y Limnogia, Unidad de Sistemas Arrecifales, Universidad Nacional Autónoma de México, Puerto Morelos 77580, Mexico.ORCID 0000-0002-9627-967X César A Pérez-EstudilloInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91000, Mexico.ORCID 0000-0002-9724-3281 María Elena Hernández-AguilarInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91000, Mexico.ORCID 0000-0002-1617-5636 María Rebeca Toledo-CárdenasInstituto de Investigaciones Cerebrales, Universidad Veracruzana, Xalapa 91000, Mexico.ORCID 0000-0003-1273-4944 Funding
Secretaría de Ciencia, Humanidades, Tecnología e Innovación 630321/33665
6 · The paper itselfAbstract
Autism Spectrum Disorder (ASD) is characterized by deficits in communication, socialization, and restricted behavioral patterns. Valproic acid (VPA) is a teratogen that, through epigenetic mechanisms, induces ASD-like phenotypes in animal models. The zebrafish (
Indexed as
animal modelautism spectrum disorderenriched environmentsocial interactionzebrafish
Identifiers
PMID42776667
PMCPMC13600019
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