Evidence map›Paper›PMID 42776636›Full record

ReviewJournal of eye movement research2026

Abnormal Fixational Eye Movements in Ophthalmic Disease: Implications for Visual Function and Clinical Assessment.

Sophia Castro, Nancy O Mahfouz, Simrat Renu, Kathiana Jeanty, Elana Safonova, Doris Prela, Ola Abozid, Ayesha Mulla, Josey M Spiers, Robert G Alexander

Abstract readReview
In one paragraph

Review in Journal of eye movement research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sophia CastroCUNY School of Medicine, New York, NY 10031, USA.
Nancy O MahfouzNew York Institute of Technology, Old Westbury, NY 11568, USA.
Simrat RenuNew York Institute of Technology, New York, NY 10023, USA.
Kathiana JeantyNew York Institute of Technology, New York, NY 10023, USA.
Elana SafonovaNew York Institute of Technology, New York, NY 10023, USA.
Doris PrelaNew York Institute of Technology, New York, NY 10023, USA.
Ola AbozidNew York Institute of Technology, New York, NY 10023, USA.
Ayesha MullaNew York Institute of Technology, New York, NY 10023, USA.
Josey M SpiersNew York Institute of Technology, New York, NY 10023, USA.
Robert G AlexanderNew York Institute of Technology, New York, NY 10023, USA.ORCID 0000-0002-5555-6554

Funding

The Effects of Cue Precision on Medical Imaging InterpretationR16GM159810 · NIGMS · NEW YORK INST OF TECHNOLOGY · PI Robert G Alexander · 2025 to 2026
$284k
New York Institute of Technology N/ANIGMS NIH HHS R16 GM159810NIH HHS 1R16GM159810-01
6 · The paper itself

Abstract

Ophthalmic disorders cause pathological abnormalities in fixational movements. Across disorders, recent studies demonstrate that fixation can be disrupted, often with reported changes in stability and other oculomotor dynamics as the conditions progress. Some of these changes are functionally linked to reduced visual acuity, degraded reading performance, and impaired binocular function. In this narrative review, we synthesize recent work on fixational eye movements and fixation instability in ophthalmic disease. We argue that fixational measures may provide research biomarkers and clinical correlates of disease progression. These metrics could eventually contribute to treatment monitoring applications. The development of accessible and non-invasive eye-tracking tools could enhance clinical interventions. Continued progress will depend on establishing robust normative datasets and determining which oculomotor metrics provide reliable clinical information across disease states.

Indexed as

fixational stabilitymicrosaccadesocular driftpreferred retinal locusvisual acuity

Identifiers

PMID42776636
PMCPMC13600084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.