ArticleJNCI cancer spectrum2026
Early-onset colorectal cancer in Sweden: increase in distal tumors but a shift in right-sided incidence, 2020-2024.
Article in JNCI cancer spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Early-onset colorectal cancer (EOCRC; age <50 years) has increased in high-income countries. We updated a nationwide Swedish cohort study with data from 2020 to 2024 to compare recent trends with those reported during 1993-2019. Using the National Cancer Register, we identified all incident EOCRC at ages 20-49 years. Temporal trends in age-standardized incidence were assessed using segmented Poisson regression with a breakpoint at 2020 to estimate annual percentage changes (APCs). A total of 1616 EOCRC cases were diagnosed during 2020-2024. Annual percentage changes for left-sided colon and rectal cancers were consistent with continued increases in incidence. In contrast, right-sided colon cancer showed a significant change in trend (P = .01), with a nonsignificant decline during 2020-2024 (APC -3.48, 95% CI = -7.88 to 1.14). These findings indicate that the continued rise in EOCRC is primarily driven by distal tumors, that is, left-sided colon and rectal cancers. Continued surveillance is needed to clarify long-term patterns and underlying drivers.
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