Evidence map›Paper›PMID 42776463›Full record

ArticleDigestive diseases and sciences2026

The Relationship Between Selective Serotonin Reuptake Inhibitor Use and Delayed Bleeding After Colorectal Endoscopic Resection: A Nationwide Retrospective Cohort Study.

Hiroki Asano, Kazuhiko Ikeuchi, Takayuki Kishida, Hiroyuki Hisada, Yosuke Tsuji, Nobutake Yamamichi, Kazuya Okushin, Seiichi Yakabi, Chihiro Takeuchi, Daisuke Ohki and 4 more

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hiroki AsanoDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Kazuhiko IkeuchiDepartment of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Takayuki KishidaDepartment of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Hiroyuki HisadaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Yosuke TsujiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan. ytsujitky@g.ecc.u-tokyo.ac.jp.
Nobutake YamamichiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Kazuya OkushinDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Seiichi YakabiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Chihiro TakeuchiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Daisuke OhkiDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Yuko MiuraDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Dai KubotaDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Takeya TsutsumiDepartment of Infectious Diseases, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Mitsuhiro FujishiroDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Funding

Japan Science and Technology Agency JPMJPR23R1
6 · The paper itself

Abstract

purposeSelective serotonin reuptake inhibitors (SSRIs) are associated with an increased risk of gastrointestinal bleeding. However, their effect on delayed bleeding after colorectal endoscopic resection (CER) remains unclear. We evaluated the association between SSRI Use and delayed bleeding risk in patients undergoing CER.

methodsWe conducted a retrospective cohort study using a nationwide Japanese database from January 2009 to August 2023. Patients undergoing CER were classified into SSRI and non-SSRI groups. The primary outcome was 30-day delayed bleeding. Inverse probability of treatment weighting (IPTW) targeting the average treatment effect among SSRI users (ATT-IPTW) was used to balance age, sex, dialysis, antithrombotic drug use, NSAID use, procedure type, liver disease, coagulation disorder, and platelet disorder.

resultsThe final cohort included 169,995 patients (2454 SSRI users and 167,541 non-SSRI users). After ATT-IPTW, all included covariates had absolute standardized mean differences <0.10. Weighted delayed bleeding incidence was 0.77% in SSRI users and 0.69% in non-SSRI users (OR, 1.12; 95% CI, 0.71-1.77; P = 0.62). No statistically significant interaction was observed between SSRI and NSAID use (P for interaction = 0.71). Findings were similar across sensitivity analyses.

conclusionNo statistically significant association was detected between SSRI use and delayed bleeding after CER. However, the limited number of bleeding events and wide confidence interval preclude exclusion of a clinically meaningful moderate increase in risk, and these findings should not be interpreted as evidence of safety or equivalence. Further evidence is needed, particularly for ESD and resection of large lesions.

Indexed as

Administrative claims databaseColorectal endoscopic resectionDelayed bleedingSelective serotonin reuptake inhibitors

Identifiers

PMID42776463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.