Evidence map›Paper›PMID 42776381›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2026

Metabolic profiling of Escherichia coli under deuterium oxide-induced stress.

Sahand Shams, Ivayla Roberts, Ahmed Nusaim Satheek Rehuman, Nigel Gotts, Yun Xu, Shwan Ahmed, Fabian Jourdan, Catherine Winder, Adam Burke, Royston Goodacre and 1 more

Abstract read
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In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sahand ShamsDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Ivayla RobertsDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Ahmed Nusaim Satheek RehumanDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Nigel GottsDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Yun XuDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Shwan AhmedDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Fabian JourdanToxalim (Research Centre in Food Toxicology, Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Catherine WinderDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Adam BurkeDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Royston GoodacreDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Howbeer MuhamadaliDepartment of Biochemistry, Cell and Systems Biology, Centre for Metabolomics Research, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK. howbeer.muhamad-ali@liverpool.ac.uk.ORCID https://orcid.org/0000-0002-1665-4717

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSome bacteria tolerate deuterium oxide (D

objectivesThis study aimed to characterise the global metabolic responses of D

methodsFive uropathogenic E. coli isolates and the reference strain E. coli K-12 MG1655, were grown in minimal medium supplemented with glucose and casamino acids containing 0%, 40%, and 80% D

resultsGrowth profiling showed strain-dependent and progressively greater inhibition with increasing D

conclusionsD

Indexed as

Deuterium OxideEscherichia coliEscherichia coli K12MetabolomeMetabolomicsStress, PhysiologicalDeuterium OxideDeuterium oxideE. coliMetabolic profilingStable isotope probing

Identifiers

PMID42776381
PMCPMC13601189

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.