Evidence map›Paper›PMID 42776377›Full record

ArticleJournal of neuro-oncology2026

nTMS-determined cortical excitability is associated with overall survival in patients with motor-eloquent glioblastoma.

José Pedro Lavrador, Ana Mirallave-Pescador, Sabina Patel, Qusai Al-Banna, Feras Fayez, Vindhya Prasad, Asfand Baig Mirza, Filippo Andrea Sinosi, Sankhya Prakashvel, Kapil Rajwani and 10 more

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Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

José Pedro LavradorDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK. josepedro.lavrador@nhs.net.
Ana Mirallave-PescadorDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Sabina PatelDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Qusai Al-BannaDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Feras FayezNational Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, WC1N 3BG, UK.
Vindhya PrasadDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Asfand Baig MirzaDepartment of Neurosurgery, Havering and Redbridge University Hospital, Rom Valley Way, Barking, Romford, RM7 0AG, UK.
Filippo Andrea SinosiDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Sankhya PrakashvelDepartment of Neurosurgery, Havering and Redbridge University Hospital, Rom Valley Way, Barking, Romford, RM7 0AG, UK.
Kapil RajwaniDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Nida KalyalDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Yasir A ChowdhuryDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Francesco MarchiDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Ali ElhagDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Laura FerrariConsiglio Nazionale delle Ricerche, Istituto di Neuroscienze, Via Volturno 39/E, 43125, Parma, Italy.
Alba Diaz BaamondeDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Jose Sadio MosqueraDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Keyoumars AshkanDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Ranjeev BhangooDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Francesco VerganiDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPreoperative prognostication in glioblastoma remains challenging despite advances in histomolecular classification. Navigated transcranial magnetic stimulation (nTMS) enables non-invasive assessment of cortical excitability, but its role as a survival biomarker remains unclear.

objectiveTo determine whether preoperative nTMS-derived cortical excitability metrics independently predict overall survival (OS) in patients with WHO grade 4 IDH-wildtype glioblastoma.

methodsThis single-centre retrospective cohort study included patients undergoing resection for motor-eloquent WHO grade 4 IDH-wildtype glioblastoma between 2018 and 2024. Preoperative nTMS mapping was used to derive the IntraM1 Excitability Score (IMES) and Cortical Excitability Score (CES). Cox regression adjusted for age, sex, neurological deficit, MGMT methylation, and extent of resection.

resultsSeventy-seven patients were included (mean age 55.4 ± 16.0 years; 41 males; mean OS 20.5 months). Lower IMES and higher CES were associated with worse OS on univariate analysis and remained independently prognostic on multivariate analysis: IMES (HR 0.16, p = 0.003) and CES (HR 2.63, p = 0.034). Bilateral nTMS improved 12-month survival prediction over unilateral mapping.

conclusionsPreoperative nTMS-derived cortical excitability metrics independently predict OS after adjustment for established prognostic factors, supporting excitability profiling as a clinically actionable prognostic tool in glioblastoma.

Indexed as

Brain NeoplasmsCortical ExcitabilityGlioblastomaMotor CortexNeuronavigationTranscranial Magnetic StimulationAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateBrain connectivityCortical excitabilityGlioblastomaMotor mappingOverall survivalPrimary motor cortexPrognosisTranscranial magnetic stimulation

Identifiers

PMID42776377

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.