Evidence map›Paper›PMID 42776288›Full record

ArticleCancer immunology, immunotherapy : CII2026

The effect and mechanism of TIPE in promoting M2 polarization through DcR3 in the microenvironment of colorectal cancer.

Shiying Zhang, Chunlin Shen, Zeyang Lin, Qiang Zhu, Yihan Feng, Liwei Sun, Chengjia Zhang, Haole Zhang, Lumin Wang, Shuyu Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shiying Zhang *Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Organ Transplantation Institute of Xiamen University, Xiamen University, Xiamen, People's Republic of China.
Chunlin Shen *Fujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Organ Transplantation Institute of Xiamen University, Xiamen University, Xiamen, People's Republic of China.
Zeyang Lin *Department of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine,Xiamen University, Xiamen, People's Republic of China.
Qiang ZhuDepartment of General Surgery, Fuzhou First General Hospital Affiliated With Fujian Medical University, Fuzhou, People's Republic of China.
Yihan FengSchool of Medicine, Xiamen University, Xiamen, 361000, Fujian, People's Republic of China.
Liwei SunSchool of Medicine, Xiamen University, Xiamen, 361000, Fujian, People's Republic of China.
Chengjia ZhangSchool of Medicine, Xiamen University, Xiamen, 361000, Fujian, People's Republic of China.
Haole ZhangFujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Organ Transplantation Institute of Xiamen University, Xiamen University, Xiamen, People's Republic of China.
Lumin WangDepartment of Pharmacy, Zhongshan Hospital (Xiamen), Fudan University, Jinhu Road 668, Xiamen City, 361015, Fujian Province, People's Republic of China.
Shuyu ChenFujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Organ Transplantation Institute of Xiamen University, Xiamen University, Xiamen, People's Republic of China.
Jiyi HuangDepartment of Nephrology, Xiamen Key Laboratory of Precision Diagnosis and Treatment of Chronic Kidney Disease, The Fifth Hospital of Xiamen, Xiamen, 361101, Fujian, People's Republic of China.
Yuhan YeDepartment of Pathology, Zhongshan Hospital of Xiamen University, School of Medicine,Xiamen University, Xiamen, People's Republic of China. yeyh2020@hotmail.com.
Xingfeng QiuDepartment of General Surgery, Xiamen Hospital of Traditional Chinese Medicine, Xiamen, People's Republic of China. qiuxingfeng1@163.com.
Guohong ZhuangFujian Provincial Key Laboratory of Organ and Tissue Regeneration, School of Medicine, Organ Transplantation Institute of Xiamen University, Xiamen University, Xiamen, People's Republic of China. zhgh@xmu.edu.cn.ORCID http://orcid.org/0000-0001-9653-627X

Funding

Fujian Provincial Department of Science and Technology No. 2021Y2018Natural Science Foundation of Fujian Province, China No. 2022J011338Natural Science Foundation of Fujian Province, China No.2026J001008Natural Science Foundation of Fujian Province, China No.2026J0011713The National Natural Science Foundation of China No. 82470763the Natural Science Foundation of Jiangxi Province,China No. 20242BAB25511Xiamen Municipal Health Care Guiding Project No. 3502Z20254ZD1166
6 · The paper itself

Abstract

backgroundElevated expression of tumor necrosis factor α-induced protein 8 (TIPE) is observed in colorectal cancer (CRC) and is known to regulate decoy receptor 3 (DcR3) expression while promoting M2 polarization of macrophages. However, the precise role of DcR3 in macrophage M2 polarization remains to be elucidated.

methodsWe employed bioinformatic analysis alongside in vitro and in vivo experimental approaches to investigate the regulatory mechanism by which TIPE influences macrophage M2 polarization in CRC.

resultsTIPE expression in CRC tissues positively correlates with M2 macrophage markers (CD206, CD163, IL-10). Functionally, TIPE promotes M2 polarization of macrophages by upregulating DcR3. Mechanistically, DcR3 binds to heparan sulfate proteoglycan 2 (HSPG2) in a heparan sulfate (HS)-dependent manner, leading to activation of the protein kinase Bα1 (AKT1) signaling pathway. AKT1 activation not only directly drives M2 polarization but also enhances macrophage chemotaxis and recruitment toward CRC cells by upregulating the chemokine CXCL8.

conclusionsThis study reveals a novel mechanism through which TIPE regulates M2 macrophage polarization and function via DcR3, offering new perspectives for the diagnosis and therapeutic targeting of CRC.

Indexed as

Colorectal NeoplasmsIntracellular Signaling Peptides and ProteinsMacrophagesReceptors, Tumor Necrosis Factor, Member 6bTumor MicroenvironmentAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMacrophage ActivationMiceProto-Oncogene Proteins c-aktSignal TransductionIntracellular Signaling Peptides and ProteinsProto-Oncogene Proteins c-aktReceptors, Tumor Necrosis Factor, Member 6bTNFRSF6B protein, humanCRCDcR3M2 polarizationTIPETumor microenvironment

Identifiers

PMID42776288
PMCPMC13601453

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.