Evidence map›Paper›PMID 42776203›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2026

Relationship between a small aortic annulus and clinical and quality-of-life outcomes in patients undergoing TAVR.

Ottavia Cozzi, Daijiro Tomii, Jonas Lanz, Dik Heg, Holger Thiele, Won-Keun Kim, Michael Joner, Christian Thilo, Stefan Toggweiler, Bernard Prendergast and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ottavia CozziDepartment of Cardiology, Bern University Hospital, Inselspital, University of Bern, Freiburgstrasse 18, CH-3010, Bern, Switzerland.
Daijiro TomiiDepartment of Cardiology, Bern University Hospital, Inselspital, University of Bern, Freiburgstrasse 18, CH-3010, Bern, Switzerland.
Jonas LanzDepartment of Cardiology, Bern University Hospital, Inselspital, University of Bern, Freiburgstrasse 18, CH-3010, Bern, Switzerland.
Dik HegDepartment of Clinical Research, University of Bern, Bern, Switzerland.
Holger ThieleHeart Centre Leipzig at Leipzig University, Leipzig, Germany.
Won-Keun KimDepartment of Cardiology, University of Giessen, Giessen, Germany.
Michael JonerGerman Heart Centre, Technical University of Munich, Munich, Germany.
Christian ThiloDepartment of Internal Medicine I, RoMed Klinikum Rosenheim, Rosenheim, Germany.
Stefan ToggweilerHeart Center Lucerne, Luzerner Kantonsspital, Lucerne, Switzerland.
Bernard PrendergastDepartment of Cardiology, St Thomas' Hospital & Cleveland Clinic London, London, UK.
Stephan WindeckerDepartment of Cardiology, Bern University Hospital, Inselspital, University of Bern, Freiburgstrasse 18, CH-3010, Bern, Switzerland.
Thomas PilgrimDepartment of Cardiology, Bern University Hospital, Inselspital, University of Bern, Freiburgstrasse 18, CH-3010, Bern, Switzerland. Thomas.pilgrim@insel.ch.ORCID http://orcid.org/0000-0001-8721-4068
SCOPE I Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA small aortic annulus is associated with impaired hemodynamics after transcatheter aortic valve replacement (TAVR). The impact on long-term clinical or patient-centered outcomes remains unclear.

aimsTo evaluate the association between aortic annulus size and long-term clinical outcomes and patient-reported health status after TAVR.

methodsIn this post-hoc analysis of the multicenter SCOPE I randomized trial, patients were categorized according to computed tomography-derived annular size (small ≤ 430 mm

resultsAmong 732 patients, 323 (44.1%) had a small and 409 (55.9%) larger annulus. Patients with a small annulus were more frequently women and had slightly higher surgical risk. Despite higher transvalvular gradients and a higher prevalence of prosthesis-patient mismatch, patients with a small annulus had no differences in all-cause mortality (18.6% vs 25.4%), heart-failure hospitalization (14.9% vs 15.6%), or patient-reported health status at 3 years, and a comparable probability of being alive with good health status (46.5% vs 43.2%; OR 0.95, 95% CI 0.63-1.44, p = 0.81). In an exploratory factorial analysis, a small annulus treated with a balloon-expandable valve was associated with a lower probability of this integrated outcome (RR 0.59, 95% CI 0.41-0.85; p for interaction = 0.004).

conclusionsPatients with small aortic annuli experience comparable long-term survival and quality-of-life recovery after TAVR. Exploratory analyses suggest that valve type may influence patient-centered outcomes in this population.

Indexed as

Kansas City Cardiomyopathy Questionnaire scoreSmall annulusTranscatheter aortic valve replacement

Identifiers

PMID42776203

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.