ArticleClinical research in cardiology : official journal of the German Cardiac Society2026
Effectiveness and clinical impact of functional post-PCI optimization-a systematic review and individual patient-data meta-analysis.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuboptimal post-PCI FFR values are associated with impaired clinical outcomes. The determinants and clinical impact of FFR improvement through optimization remain unclear. This study sought to evaluate the effect of post-PCI optimization on fractional flow reserve (FFR) values and to identify predictors of successful optimization.
methodsWe performed a systematic review and individual patient data (IPD) meta-analysis including patients who underwent PCI with drug-eluting stents with paired FFR measurements before and after post-PCI optimization. A one-stage meta-analysis was performed using mixed-effects models. The primary endpoint was the absolute increase in FFR after optimization.
resultsOut of 1945 screened studies, a total of 11 studies met the selection criteria for the present meta-analysis and IPD was provided from 8 studies. In 314 patients, the median (interquartile range) FFR value significantly improved from 0.81 (0.75-0.85) to 0.86 (0.81-0.89) after optimization (p < 0.001). In multivariable analysis, LAD vessel and higher post-PCI FFR values were negative predictors for the magnitude of FFR increase, whereas optimization using an additional stent was associated with a larger FFR increase as compared to post-dilatation alone. The effect of additional stenting was more pronounced in patients with lower post-PCI FFR values.
conclusionsPost-PCI optimization after angiographically successful PCI resulted in a significant increase in post-PCI FFR. The success of optimization of suboptimal FFR values was associated with target vessel location, initial post-PCI FFR value and optimization method.
Indexed as
Identifiers
42776202What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.