Evidence map›Paper›PMID 42776010›Full record

ArticleGut microbes2026

A probiotic

Zhao-Qing Shen, Tran Thi Dieu Thuy, Chung-Kuang Lu, Thanh-Sang Nguyen, Chien-Yi Tung, Cheng-Yen Kao, Ting-Fen Tsai

Abstract read
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In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhao-Qing ShenDepartment of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0001-9126-0219
Tran Thi Dieu ThuyInstitute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0009-0003-0020-3465
Chung-Kuang LuDepartment of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0003-4243-4547
Thanh-Sang NguyenNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei, Taiwan.
Chien-Yi TungThe National Genomics Center for Clinical and Biotechnological Applications, Cancer and Immunology Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Cheng-Yen KaoInstitute of Microbiology and Immunology, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0001-8782-3912
Ting-Fen TsaiDepartment of Life Sciences and Institute of Genome Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.ORCID 0000-0003-3239-4430

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary flavonoids often require microbial metabolism to generate bioactive metabolites that influence host physiology. Hesperidin, a citrus flavanone glycoside, exhibits limited intestinal absorption and depends on gut microbial biotransformation to yield its active aglycone, hesperetin. Hesperetin activates CDGSH iron-sulfur domain 2 (CISD2), a pro-longevity gene whose expression declines with age, and its pharmacological activation has emerged as a strategy to promote healthy aging. Here, we identified a probiotic strain,

Indexed as

AgingBifidobacterium pseudocatenulatumHesperidinProbioticsAnimalsBiotransformationEnergy MetabolismMaleMiceMice, Inbred C57BLhesperetinHesperidinBifidobacterium pseudocatenulatumCISD2 activatorglucose homeostasishealthy aginghesperetininsulin resistancemetabolic dysfunction-associated fatty liver disease (MAFLD)sarcopenia

Identifiers

PMID42776010
PMCPMC13613915

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.