Trial reportAging cell2026
Associations Between Gut Microbiota and Immune Profiles in Community-Dwelling Older Adults and the Regulatory Role of Polygonatum odoratum.
Trial report in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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18 authors.
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Abstract
Aging is often associated with intestinal microbiota imbalance and immune system degeneration. The dysregulation and crosstalk of these two factors markedly elevate the elderly's susceptibility to infections and age-related diseases. Polygonatum odoratum, a traditional Chinese medicinal herb, is widely used in geriatric care for its lung-moistening and nourishing effects. However, its potential regulatory roles on the microbiota and immunity in the aging context remain unreported. A total of 140 independently living elderly individuals aged 60 and above were recruited for this study. The randomized, double-blinded study including YZG (P. odoratum) and placebo groups was performed for 90 days' intervention. Peripheral blood immune cell subsets were analyzed by flow cytometry, and microbial diversity in fecal samples was assessed by 16S rRNA sequencing. Baseline correlation analysis revealed that alterations in gut microbiota were predominantly associated with T cell subsets. Specifically, Akkermansia showed a significant negative correlation with age-related memory T cells, including CD4
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