Evidence map›Paper›PMID 42775623›Full record

ArticleMovement disorders clinical practice2026

Should Paratonia Be Considered a Movement Disorder? Implications for Clinical Management.

Galit Kleiner, Christos Ganos, Anthony E Lang

Abstract read
In one paragraph

Article in Movement disorders clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Galit KleinerAustin Centre for Neurology and Behavioral Supports, Baycrest Health Sciences, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-5261-2509
Christos GanosDivision of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0001-8077-8530
Anthony E LangDivision of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-1229-3667

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paratonia is an involuntary and variable resistance to passive movement that emerges with cognitive decline in dementias of different etiologies, with prevalence approaching 90% to 100% in end-stage disease. It is common in Parkinson disease and the atypical parkinsonisms. The involuntary resistance is frequently interpreted as volitional refusal of care and may be managed with psychotropic medication. We propose that paratonia meets the criterion by which a movement disorder is defined, with a reproducible and distinct clinical phenomenology that is operationalized in a validated bedside instrument and is distinguishable from parkinsonian rigidity, spasticity, and dystonia. We present a preliminary staging schematic in which treatment with botulinum toxin A (BoNT-A) is indicated when the posturing interferes with care and the contraction remains dynamic, before fixed contracture. Preliminary evidence from a randomized pilot trial and observational studies supports BoNT-A for care-interfering paratonia. Classification of paratonia as a movement disorder would enable a dedicated research, education and advocacy platform to advance clinical care.

Indexed as

botulinum toxincaregiver burdenclassificationdementiamovement disordersparatonia

Identifiers

PMID42775623
PMCPMC13598939

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.