Evidence map›Paper›PMID 42775459›Full record

ArticleCirculation. Arrhythmia and electrophysiology2026

Effect of Pulsed Field Timing Sequence and Electrode Cooling on Ablation Safety and Efficacy Surrogates: A Preclinical Study.

Luigi Di Biase, Jonathan Hsu, Rahul Bhardwaj, David Newton, William Maddox, Jorge E Romero, Tara Gomez, Eric Byun, Qi Chen, Christopher Beeckler and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Luigi Di BiaseDepartment of Cardiology, Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Bronx, NY (L.D.B., F.Z.).ORCID 0000-0001-6508-4047
Jonathan HsuCardiac Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Diego (J.H.).ORCID 0000-0002-1523-573X
Rahul BhardwajDepartments of Cardiology and Electrophysiology, Loma Linda University Medical Center, Loma Linda University International Heart Institute, CA (R.B.).ORCID 0000-0001-7734-8660
David NewtonClinical Cardiac Electrophysiology Department, Memorial Health University Medical Center, Savannah, GA (D.N.).
William MaddoxUniversity of Alabama at Birmingham (W.M.).ORCID 0000-0002-5529-3221
Jorge E RomeroHeart and Vascular Institute, Upstate Medical University, Syracuse, NY (J.E.R.).ORCID 0000-0001-6420-8669
Tara GomezJohnson & Johnson MedTech, Irvine, CA (T.G., E.B., Q.C., C.B.).ORCID 0000-0002-8885-1891
Eric ByunJohnson & Johnson MedTech, Irvine, CA (T.G., E.B., Q.C., C.B.).ORCID 0009-0003-9389-2369
Qi ChenJohnson & Johnson MedTech, Irvine, CA (T.G., E.B., Q.C., C.B.).
Christopher BeecklerJohnson & Johnson MedTech, Irvine, CA (T.G., E.B., Q.C., C.B.).
Fengwei ZouDepartment of Cardiology, Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Bronx, NY (L.D.B., F.Z.).ORCID 0000-0001-6355-8843
William H SauerCardiac Arrhythmia Service, Brigham and Women's Hospital, Boston, MA (W.H.S.).ORCID 0009-0006-8556-3612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe variable loop circular catheter has been shown to be a safe, effective pulsed field ablation catheter for atrial fibrillation treatment. After the commercial launch of the initial waveform (Seq1), a new waveform (Seq2

methodsTwenty-four Yorkshire pigs were treated with pulsed field ablation using the variable loop circular catheter. Subjects were randomized into 3 pulse recipe/irrigation arms (Seq1

resultsIn all groups, 100% acute and chronic pulmonary vein isolation effectiveness was observed, as indicated by transmural, circumferential, pulmonary vein lesions with no evidence of collateral injury. Transmurality in the left atrial appendage, LA roof, and posterior wall was 75% to 100% across all groups and absent at the mitral isthmus. No catheter thrombus/char was observed at Seq2

conclusionsConsistently durable pulmonary vein isolation was observed across all groups, including Seq1

Indexed as

Atrial FibrillationCardiac CathetersCatheter AblationPulmonary VeinsAnimalsEquipment DesignFemaleIrreversible Electroporation TherapySus scrofaSwineTherapeutic IrrigationTime Factorsanimalsatrial fibrillationcatheter ablationhemolysismicrobubbles

Identifiers

PMID42775459
PMCPMC13686642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.