ReviewClinical pharmacology and therapeutics2026
The Hidden Cost of QTc Assessment: A Quantitative Weight of Evidence Framework to Eliminate Structural False Positives and Restore the Lost Opportunity Cost of Abandoned Medicines.
Review in Clinical pharmacology and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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Authors and funding
3 authors.
Funding
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Abstract
The regulatory framework for QTc assessment has been optimized against false negatives while ignoring the false positives that silently remove efficacious medicines from development. False positives arise from three independent, compounding sources. First, a structural source: sensitive tests applied in low-prior populations generate predominantly false positives as a mathematical inevitability. Second, a measurement artifact: patch-clamp electrophysiology systematically biases hERG IC
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.