ArticleFrontiers in genetics2026
Perceptions of and willingness to participate in genomics research among a U.S. sample.
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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12 authors.
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Abstract
Introduction: The proliferation of biobanks and the collection of gender identity data have created opportunities to conduct transgender identity genetic research (TIGR), which explores possible genetic contributions to gender identity. However, without meaningfully engaging trans communities, researchers may struggle to understand and prevent potential harms while maximizing potential benefits, particularly when research fails to incorporate the social, medical, and political factors and environments shaping transgender peoples' lives. This study explored factors associated with transgender individuals' perspectives on and willingness to participate in TIGR. Methods: Between January and May 2025, we recruited a nationwide sample (n = 495) of transgender adults. Participants completed a cross-sectional survey assessing sociodemographics, policy safety, health, TIGR perspectives, and willingness to participate in TIGR. Regression models assessed correlates of TIGR perspectives and willingness to participate. Results: Participants' median age was 29 years (IQR = 25-34); 38.4% were people of color. While 62.2% would be willing to participate, 68.9% agreed TIGR could harm transgender communities. More positive TIGR perspectives were observed among people of color (aβ = 0.48, 95% CI = 0.18 to 0.56) and those experiencing food insecurity (aβ = 0.21, 95% CI = 0.02 to 0.40). Less favorable perspectives were associated with disability (aβ = -0.20, 95% CI = -0.38 to -0.02), medical gender affirmation (aβ = -0.30, 95% CI = -0.54 to -0.06), mixed vs. negative transgender policy environment (aβ = -0.32, 95% CI = -0.59 to -0.05), and high medical mistrust (aβ = -0.24, 95% CI = -0.46 to -0.03). Positive perspectives were strongly associated with willingness to participate in TIGR (aOR = 14.48, 95% CI = 7.30 to 28.70). Discussion: Although most participants were willing to participate in TIGR, a substantial minority were unsure or unwilling, reflecting concerns about trust, risk, and benefits. Future genomics research involving transgender people must prioritize trust-building efforts, particularly those that ensure participant safety, to encourage future research participation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.