ReviewThe archives of bone and joint surgery2026
The Impact of Vitamin D Supplementation on Postoperative Outcomes Following Total Joint Arthroplasty: A Systematic Review.
Review in The archives of bone and joint surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This systematic review examines the effects of vitamin D supplementation on postoperative outcomes following total knee and hip arthroplasty, taking into account its role in musculoskeletal health and the high prevalence of vitamin D deficiency among arthroplasty patients. Methods: A comprehensive search of PubMed, Scopus, Embase, and Web of Science was conducted through April 2026. Eligible studies included randomized clinical trials assessing vitamin D supplementation in patients undergoing total knee or hip arthroplasty. Two reviewers independently screened studies, extracted data, and evaluated methodological quality using the Cochrane RoB-2 tool. Due to substantial methodological heterogeneity, a qualitative synthesis was performed. Results: Five randomized controlled trials comprising 519 patients were included. Higher-dose and oral regimens resulted in greater increases in serum 25(OH)D levels, including higher postoperative concentrations with 2000 IU versus 800 IU at 24 months (45.5 vs. 37.1 ng/mL) and with oral versus intramuscular administration of 600,000 IU on postoperative day 14. However, most studies reported no significant between-group differences in functional outcomes, pain scores, complications, or other clinical endpoints. One study demonstrated significantly greater muscle strength in the supplementation group, including hip abductor strength (P = 0.03) and knee extensor strength (P = 0.01). Conclusion: Vitamin D supplementation appears to improve perioperative vitamin D status, particularly with higher-dose and oral regimens. However, current evidence for consistent benefits on broader postoperative functional and clinical outcomes after joint arthroplasty remains limited and inconclusive. Level of evidence: II.
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