ArticleClinical interventions in aging2026
Longitudinal Dynamics of Pain, Fatigue, Anxiety-Depression, Sleep, and Functional Limitation in Older Adults with Rheumatoid Arthritis: A Cross-Lagged Panel Network Analysis.
Article in Clinical interventions in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the longitudinal dynamics of five symptoms -pain (P), fatigue (F), anxiety-depression (A), sleep disturbance (S), functional limitation (FL)- in older patients with rheumatoid arthritis (RA), to identify longitudinal predictive relationships among these symptoms, and to inform individualized symptom management. Methods: A prospective longitudinal study enrolled eligible RA patients from August 2025 to February 2026. Five symptoms were assessed at hospitalization (T1) and one month after discharge (T2). Cross-sectional networks compared inpatient and outpatient symptom covariation, and Cross-Lagged Panel Network (CLPN) analysis evaluated longitudinal predictive associations and network stability. Results: A total of 177 participants completed data collection. All edges in the cross-sectional networks were positive. The most central symptoms at both T1 and T2, as indicated by expected influence, were functional limitation and fatigue. CLPN analysis revealed that fatigue was the only symptom with significant longitudinal predictive effects: it positively predicted subsequent sleep disturbance (β = 0.250, 95% CI [0.038, 0.621]) and functional limitation (β = 0.045, 95% CI [0.016, 0.068]) at T2. Anxiety-depression had the highest in-expected influence (In‑EI = 0.819), indicating that it was most susceptible to being predicted by other symptoms. Network stability was satisfactory (CS coefficients > 0.6 for both Out‑EI and In‑EI). Conclusion: During the transition from inpatient to outpatient care in older RA patients, fatigue emerges as the primary longitudinal predictor of subsequent sleep disturbance and functional limitation, whereas anxiety-depression exhibited the highest susceptibility to being predicted by other symptoms. These findings may inform future symptom management strategies and generate hypotheses for interventional research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.