ArticleInfection and drug resistance2026
Bronchoalveolar Lavage Microbiota in Critically Ill Patients with Aspiration Pneumonia: An Exploratory Comparison with Community-Acquired Pneumonia and Analysis of
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Aspiration pneumonia (AP) is a common and severe infection among critically ill older adults, but its lower respiratory tract microbiota and clinical associations remain incompletely characterized. Methods: This single-center retrospective exploratory study included 72 intensive care unit patients, comprising 49 patients with AP and 23 with community-acquired pneumonia (CAP). Bronchoalveolar lavage fluid (BALF) microbiota were profiled using metagenomic next-generation sequencing (mNGS). Alpha and beta diversity, taxonomic composition, differential abundance, and associations between bacterial taxa and clinical or peripheral immune markers were analyzed. Within the AP cohort, the association between Results: AP patients had higher Shannon and Simpson diversity than CAP patients. Overall community composition did not differ significantly between the groups based on Bray-Curtis dissimilarity and PERMANOVA (R Conclusion: AP was associated with higher alpha diversity. Selected oral-associated taxonomic patterns and their immune-cell percentages correlations were exploratory and were not confirmed after multiple-testing correction. The association between
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