ArticleFASEB bioAdvances2026
Blue Light Exposure Induces Changes Associated With Senescence and Skin Aging in Human Dermal Fibroblasts.
Article in FASEB bioAdvances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Blue light is becoming increasingly prevalent in our daily lives. However, the possible deleterious effects of blue light exposure on the skin have been largely overlooked. We have previously shown that blue light has the ability to induce mitochondrial DNA (mtDNA) damage and dysfunction in human dermal fibroblasts (HDFn). However, whether blue light is able to induce senescence in skin has yet to be investigated. Cellular senescence is a key part of the aging process and is heavily associated with an aging phenotype. Our study involved exposing HDFn to varying doses of blue light before assessing the expression of known senescence markers using both immunofluorescence and gene expression qPCR. We also assessed beta-galactosidase activity using a senescence-associated beta-galactosidase (SA β-gal) staining kit. Blue light induces increased γH2AX expression (
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