Effectiveness of Tamaru method plasma therapy: Overview and the original method.

The rapid aging of the population in Japan has led to an increased incidence of cancer, creating a demand for effective therapeutic options with minimal physical and financial burden. Non-equilibrium atmospheric pressure plasma (NEAPP), or low-temperature plasma, has emerged as a promising modality in oncology. The present study summarizes the fundamental principles of NEAPP and its therapeutic applications in cancer treatment. The authors first provide an overview of established approaches, such as the direct irradiation of cancer cells and the indirect use of plasma-activated medium, which have been shown to induce apoptosis in malignant cells. Subsequently, the authors introduce a novel therapeutic system, the Tamaru Method Plasma Therapy, developed by the authors' research group. This system combines a unique plasma-generating device, termed Plasma AIAS, with the oral intake of plasma-activated water. The proposed mechanism of this non-invasive method is the systemic enhancement of intracellular adenosine triphosphate production and the generation of nitric oxide. This dual action is expected to improve microcirculation and exert anti-tumor effects, while maintaining a high safety profile. The present study highlights the potential of this original method as a next-generation therapy for cancer, addressing the needs of modern medical care.