SynthesisFrontiers in nutrition2026
A CE/TA-stratified systematic review and evidence map of matcha and green tea bioactives in endocrine stress regulation: testosterone, cortisol, and the T:C ratio.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Matcha and green-tea bioactives are widely promoted for stress and hormonal health, yet the evidence is fragmented across chemically dissimilar preparations (whole-leaf matcha, brewed green tea, isolated L-theanine, and concentrated epigallocatechin-3-gallate, EGCG) that are routinely treated as interchangeable. A compositional index for this problem already exists: the caffeine-plus-EGCG-to-L-theanine-plus-arginine (CE/TA) molar ratio, developed by Unno and colleagues for matcha and Japanese green-tea preparations, together with an indicative screening threshold. This review adopts that index and applies it, for the first time, as a stratification variable across a formally assembled endocrine evidence base, in order to map what is and is not established regarding cortisol, testosterone, and the testosterone-to-cortisol (T:C) ratio. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement and its search extension (PRISMA-S), seven electronic sources were searched from inception to March 31, 2026, and findings were synthesized using the Synthesis Without Meta-analysis (SWiM) guideline because the studies were not sufficiently comparable for meta-analysis. Twenty-two studies were included (700 human participants; 673 endocrine-relevant), spanning randomized controlled trials, nonrandomized interventions, a cross-sectional study, animal experiments, and
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