ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2026
Comparison of arterial blood pressure and quality of induction and recovery in horses anesthetized with diazepam or guaifenesin co-induction combined with xylazine and ketamine and maintained on isoflurane.
Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The objective of this prospective alternating crossover study was to compare quality of induction and recovery and cardiopulmonary function in horses administered guaifenesin or diazepam as co-induction drugs. Six healthy horses were anesthetized twice to undergo an MRI and surgical biopsies, with 5 wk between treatments. Horses were sedated intravenously (IV) with xylazine, 0.6 mg/kg BW, and IV induction started 4 min later. Group G received guaifenesin, 100 mg/kg BW, over 2 min and ketamine, 2 mg/kg BW, within 1 to 2 min of starting the guaifenesin. Group D received diazepam, 0.1 mg/kg BW, within 5 s and ketamine, 2 mg/kg BW, 0.5 to 1 min after and the quality of induction assessed. Horses were positioned on an MRI-compatible table, the trachea intubated, allowed to breathe spontaneously for the initial 10 min, then connected to a rebreathing circuit and anesthetic machine and mechanically ventilated under anesthesia [end-tidal isoflurane (F
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