ArticleEnvironment & health (Washington, D.C.)2026
Prenatal Exposure to Persistent Organic Pollutants Is Associated with Altered Lipid and Metabolomic Profiles in Mothers and Newborns.
Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Maternal exposure to persistent organic pollutants (POPs) has been linked with adverse pregnancy and birth outcomes, yet the underlying biological pathways involved remain poorly characterized. In this study, we examined associations between POP concentrations in maternal plasma and cord blood and metabolomic and lipidomic profiles of pregnant women and their newborns and further assessed relationships with neonatal birth weight. A total of 257 mother-infant dyads were included. Concentrations of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCs) were quantified using gas chromatography coupled with atmospheric pressure tandem mass spectrometry (GC-MS/MS). Metabolomic profiling was performed using gas chromatography coupled with quadrupole time-of-flight mass spectrometry (GC-QTOFMS) and ultrahigh-performance liquid chromatography-QTOFMS (UHPLC-QTOFMS). In maternal plasma, POP exposure was predominantly associated with variations in free fatty acids, phospholipids, and triacylglycerols. The strongest associations were observed for
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