ArticleChemical science2026
Single-monosaccharide resolution glycan profiling enabled by the nanopipette.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Glycans encode critical biological information through variations in monosaccharide composition, branching architecture, and chemical modifications. However, decoding these structural features with single-monosaccharide precision at physiological (nM-µM) concentrations remains a major challenge. Herein, we develop a rectification-guided nanopipette strategy that identifies individual monosaccharide differences in heparosan oligosaccharides at picomolar concentrations. This capability arises from an optimized ionic current rectification ratio, which results in a suitable balance between electroosmotic flow (EOF) and electrophoretic force (EPF), thereby enabling enhanced capture efficiency and signal-to-noise ratio. The success rate of single-molecule glycan detection increases from below 20% to over 80%, enabling reliable discrimination of linear and branched oligosaccharides with single-monosaccharide resolution and over 98% accuracy. Combining high sensitivity with single-monosaccharide resolution, this method provides a promising platform for nanopore-based glycomics and sequencing.
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