Evidence map›Paper›PMID 42775135›Full record

ArticleiScience2026

A plant DNMT3 induces non-CG methylation and affects gene expression in human cells.

Rotem Domb, Karina G Heskiau, Aviva Katz, Rafael Yaari, Rachel Zamostiano, Keith D Harris, Eran Bacharach, Nir Ohad, Assaf Zemach

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rotem DombSchool of Plant Sciences and Food Security, Tel-Aviv University, Tel-Aviv 69978, Israel.
Karina G HeskiauSchool of Plant Sciences and Food Security, Tel-Aviv University, Tel-Aviv 69978, Israel.
Aviva KatzSchool of Plant Sciences and Food Security, Tel-Aviv University, Tel-Aviv 69978, Israel.
Rafael YaariSchool of Plant Sciences and Food Security, Tel-Aviv University, Tel-Aviv 69978, Israel.
Rachel ZamostianoThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv-Yafo, Israel.
Keith D HarrisSchool of Plant Sciences and Food Security, Tel-Aviv University, Tel-Aviv 69978, Israel.
Eran BacharachThe Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv-Yafo, Israel.
Nir OhadSchool of Plant Sciences and Food Security, Tel-Aviv University, Tel-Aviv 69978, Israel.
Assaf ZemachSchool of Plant Sciences and Food Security, Tel-Aviv University, Tel-Aviv 69978, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CG methylation is the predominant form of DNA methylation across eukaryotes, whereas non-CG methylation in vertebrates is largely restricted to neurons and embryonic stem cells and is mediated by DNMT3 enzymes. In contrast, plant DNMT3 homologs catalyze extensive non-CG methylation across diverse tissues. To test whether a plant DNMT3 can establish non-CG methylation and influence transcription in human cells, we expressed

Indexed as

DNA methylationMeCP2neuronsnon-CG methylationnon-CpG methylation

Identifiers

PMID42775135
PMCPMC13595168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.