ArticleToxicology reports2026
Acute, high dose ethylene glycol administration produces no neuroinflammation, no abnormal brain or liver histology, significant urinary oxalate excretion, and minimal nephrotoxicity in male CD-1 mice.
Article in Toxicology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The hallmarks of ethylene glycol (EG) toxicity are very well characterized in rat and female mouse models, and includes glycolate-mediated metabolic acidosis with calcium oxalate monohydrate (COM) target-organ accumulation. However, high dose, acute EG target organ toxicity has yet to be assessed in male CD-1 mice. Therefore, our studies utilize 9-week-old, male CD-1 mice to assess EG toxicity at 3 concentrations (3, 6, and 12 g/kg) in the mouse for 24, 48, and 72 h. Results indicate that 6 and 12 g/kg EG induce a 2.5-fold increase in serum creatinine 72h-post gavage with minor kidney damage, and no COM crystal tissue deposition with majority of oxalate being excreted in the urine. Oxalate alone (4 and 10 mM) induces a 27% and 31% decrease in ATP, respectively after 6 and 12 h in mouse proximal tubule cells
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