ArticleAdvanced biomedical research2026
Homing Assessment of Human Placenta-Derived Mesenchymal Stromal Cells in Immunodeficient NOG Mice Following Sublethal Irradiation.
Article in Advanced biomedical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Mesenchymal stromal cells (MSCs) are among the most extensively studied candidates for cell-based therapy. The homing capacity of MSCs is a critical factor influencing the efficacy of MSC-based therapies. This study aimed to investigate the homing of placenta-derived mesenchymal stromal cells (PD-MSCs) in various damaged tissues of immunodeficient Cg-PrkdcscidIl2rgtm1Sug/ShiJic (NOG) mice in response to total body irradiation (TBI). Materials and Methods: NOG mice were irradiated with 3.5 Gy. PD-MSCs were isolated, characterized, and transduced with green fluorescent protein (GFP). Twenty-four hours after irradiation, 250 × 10 Results: A weak band was detected in some PCR samples following GFP-PD-MSCs injection; however, the presence of these cells was not confirmed by flow cytometry or IHC. Conclusion: Intravenous infusion of GFP-PD-MSCs did not result in detectable homing to various damaged tissues in response to TBI. This suggests that the inability of these cells to home effectively may limit their therapeutic potential.
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