ArticleAnnals of surgery open : perspectives of surgical history, education, and clinical approaches2026
The Benign COMPARE Study: Comparing Perioperative Outcomes of Benign Minimally Invasive Laparoscopic, da Vinci Robotic, and Open Procedures: A Systematic Review and Meta-Analysis of Evidence.
Article in Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
10 authors.
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Abstract
Objectives: To assess perioperative and quality-of-life outcomes of da Vinci robotic-assisted surgery (dV-RAS), laparoscopic, and open surgery for 13 benign procedures. Background: Prior studies demonstrate dV-RAS benefits in oncologic procedures, but potential benefits in benign procedures remain undetermined. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses-guided systematic searches (PROSPERO CRD420251001402) of PubMed, Scopus, and Embase (last searched October 22, 2025) identified randomized controlled trials (RCTs), database studies, and comparative cohort studies (2010-2024). Primary endpoints included operative time (OT), transfusions, length of stay (LOS), conversions, intraoperative and postoperative complications, surgical site infections (SSIs), readmissions, reoperations, and mortality. Secondary endpoints included pain, pain medication use, return to activities of daily living (ADL), and return to work (RTW). Pooled odds ratios (ORs), risk differences, or mean differences (MD) were estimated using fixed or random-effects models, with bias assessed using Risk of Bias in Non-Randomized Studies of Interventions and Cochrane risk-of-bias tool for randomized trials. Results: Three hundred sixty-six studies (13 RCTs, 21 prospective, 101 database, and 231 retrospective) comprising 1,469,565 dV-RAS, 10,699,092 laparoscopy, and 1,730,656 open patients were analyzed. Compared with open surgery, dV-RAS was associated with fewer transfusions [OR, 0.31 (0.24-0.42); Conclusions: dV-RAS was associated with fewer conversions, less pain, and faster recovery compared with open and laparoscopic surgery, supporting its effectiveness for benign indications.
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