Evidence map›Paper›PMID 42775049›Full record

ReviewFrontiers in aging2026

Molecular markers, mechanisms and metrics of biological aging: a scoping review.

Alison Ziesel, Jennifer Reeves, Anastasia Mallidou, Lorelei Newton, Ryan E Rhodes, Jie Zhang, Theone Paterson, Hosna Jabbari

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alison ZieselDepartment of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.
Jennifer ReevesDepartment of Psychology, University of Victoria, Victoria, BC, Canada.
Anastasia MallidouSchool of Nursing, University of Victoria, Victoria, BC, Canada.
Lorelei NewtonSchool of Nursing, University of Victoria, Victoria, BC, Canada.
Ryan E RhodesInstitute on Aging and Lifelong Health, University of Victoria, Victoria, BC, Canada.
Jie ZhangInstitute on Aging and Lifelong Health, University of Victoria, Victoria, BC, Canada.
Theone PatersonDepartment of Psychology, University of Victoria, Victoria, BC, Canada.
Hosna JabbariDepartment of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological aging is a rapidly growing area of research, which entails characterizing the rate of aging independent of an individual's chronological age. In this scoping review, we analyze the results of biological aging research in 435 papers published in a 12 year window spanning 2011 through June 2023, 309 of which focus on non-methylation-based biomarkers, revealing changing patterns of molecular markers of biological aging use over time as well as the development of novel metrics of biological aging. We further identify consistent and discordant research findings, as well as areas of potential future research focusing on questions of measurement with biomarker-based assessment and other variables relevant to the study of biological age.

Indexed as

biological agebiological clocksblood-based biomarkersmetabolitesmolecular biomarkers

Identifiers

PMID42775049
PMCPMC13595061

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.