ReviewCureus2026
Impact of Premorbid Function and Comorbidities in Geriatric Traumatic Brain Injury Patients: A Systematic Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Population aging is increasing geriatric traumatic brain injury (TBI), with outcomes depending on premorbid health beyond chronological age. This systematic review examined how premorbid functional status, frailty, and comorbidities influence mortality, functional recovery, and other outcomes in adults aged ≥60 years with TBI. Following the PRISMA 2020 statement, PubMed, Scopus, Web of Science, and Google Scholar were searched (2016-2026). Twenty observational studies (n = 128,793) were included. Narrative synthesis was performed; risk of bias was assessed with Joanna Briggs Institute tools. Frailty (Clinical Frailty Scale, Fatigue, Resistance, Ambulation, Illness, and Loss of weight (FRAIL) Scale, and Hospital Frailty Risk Score) and premorbid ADL dependence consistently predicted higher mortality, unfavorable Glasgow Outcome Scale-Extended scores, prolonged hospitalization, and adverse discharge disposition. Comorbidities (diabetes, chronic kidney disease, and cardiovascular disease) independently worsened neurological recovery and increased complications. Frailty measures provided prognostic value superior to age alone after adjustment for injury severity. In conclusion, premorbid functional status, frailty, and comorbidities are key determinants of outcome in geriatric TBI. Routine frailty and comorbidity assessment should be integrated into clinical evaluation and prognostic models to improve risk stratification and guide individualized management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.