ArticleJournal of medical biochemistry2026
Oxidative stress biomarkers and chondrocyte apoptosis as predictors of postoperative outcomes in osteonecrosis of the femoral head.
Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteonecrosis of the femoral head (ONFH) is a progressive disease where oxidative stress and chondrocyte apoptosis contribute to cartilage degeneration and postoperative complications. Identifying reliable biochemical markers is essential for prognosis after hip resurfacing arthroplasty (HRA). Methods: A retrospective analysis was conducted in 134 ONFH patients (ARCO stage II-III) treated with HRA. Serum oxidative stress markers-reactive oxygen species (ROS), superoxide dismutase (SOD), and malondialdehyde (MDA)-were measured preoperatively and at serial postoperative timepoints. Chondrocyte apoptosis rates were assessed by flow cytometry. Pain and functional recovery were evaluated using VAS and Harris hip scores. Correlation, univariate, and Cox regression analyses were applied to determine associations with postoperative outcomes. Results: Patients with high oxidative stress had significantly increased ROS and MDA levels, reduced SOD activity, and elevated chondrocyte apoptosis (P<0.05). These patients showed delayed functional recovery and higher complication rates. Strong correlations were observed between oxidative markers and apoptosis (ROS: r=0.912; MDA: r=0.901; SOD: r=-0.875). Cox regression identified ROS, MDA, reduced SOD, and apoptosis as independent risk factors for postoperative failure (HR range: 1.06-1.49, all P<0.05). Conclusions: Serum oxidative stress markers and chondrocyte apoptosis rates are closely linked to joint recovery and complications after HRA in ONFH patients. These biochemical indicators may serve as prognostic biomarkers, supporting early identification of high-risk individuals and guiding personalized postoperative interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.