ArticleClinical neurophysiology practice2026
Acute administration of methylphenidate modulates functional connectivity during irrelevant stimuli processing in Parkinson's disease.
Article in Clinical neurophysiology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Methylphenidate (MPD) may have therapeutic benefits in Parkinson's disease (PD) patients. However, the effects of MPD on attentional functional connectivity (FC) networks, in PD, have not been investigated to date. Our objective was to examine the effects of a single dose of MPD, on event-related FC, in PD. The study was a randomized, double-blind, placebo-controlled, single-dose, cross-over clinical trial. Methods: We recorded electroencephalogram (EEG) in PD patients during the performance of an extended version of a visual oddball task. We evaluated FC during the processing of task-relevant (targets, predictive sequence) and task-irrelevant (randomized standards) stimuli, using the weighted phase-locking index and graph theory. Two recording sessions (20 mg MPD or placebo) were performed in each patient. Results: MPD, in comparison with placebo, modulated FC during the processing of standards, within the theta band, in PD patients. MPD induced decreases in the FC and global efficiency within fronto-parietal networks, during the processing of task-irrelevant stimuli. Conclusions: In PD patients, the administration of a single dose of MPD, compared with placebo, attenuated FC within fronto-parietal networks, during the processing of non-informative standards. Significance: MPD may have cognitive therapeutic effects in PD, by modulating attention during the processing of task-irrelevant stimuli.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.