ArticleJournal of molecular and cellular cardiology plus2026
Systemic administration of the PRMT5 inhibitor GSK3326595 does not induce overt cardiotoxicity in the murine heart.
Article in Journal of molecular and cellular cardiology plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein Arginine Methyltransferase (PRMT5) has emerged as a promising target for antineoplastic strategies. Given its oncogenic properties in promoting tumorigenesis and metastasis of several cancer entities, pharmacological approaches to inhibit the enzymatic activity of PRMT5 (PRMT5i) have gained particular attention. Among others, GSK3326595 is currently evaluated in clinical studies for the treatment of hematological malignancies. However, besides the pathophysiological relevance, PRMT5 is a ubiquitously expressed enzyme with essential cellular functions. Previous studies uncovered a substantial role in cardiomyocytes along with heart failure caused by loss of PRMT5 raising the question if PRMT5i may exert adverse effects on the cardiovascular system. Thus, we conducted comprehensive pharmacokinetic profiling of GSK3326595 in mice. We found that systemic administration leads to a homogenous distribution across organs and tissues. While major depression of hematopoiesis could be detected, we did not find detrimental impact on systolic function, cardiac morphology and homeostasis indicating differential pharmacodynamics on proliferating and postmitotic cells. In conclusion, systemic treatment with GSK3326595 shows no overt effects on the murine heart under the conditions tested in this study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.