Evidence map›Paper›PMID 42774980›Full record

ArticleIJID regions2026

Associations of serum 25-hydroxyvitamin D and vitamin D receptor polymorphisms with dengue severity in hospitalized Vietnamese children.

Phan Viet Hung, Nguyen Minh Phuong, Nguyen Thi Cam Tien, Tran Thi Huynh Nhu, Pham Minh Quan, Truong Van Dat, Nguyen Thi Thuy Duong, Thai Minh Dien, Trinh Nhut Truong, Hua Kim Chi and 2 more

Abstract read
In one paragraph

Article in IJID regions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Phan Viet HungFaculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam.
Nguyen Minh PhuongFaculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam.
Nguyen Thi Cam TienFaculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam.
Tran Thi Huynh NhuFaculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam.
Pham Minh QuanFaculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam.
Truong Van DatCa Mau Obstetrics and Pediatrics Hospital, Ca Mau City, Vietnam.
Nguyen Thi Thuy DuongCa Mau Obstetrics and Pediatrics Hospital, Ca Mau City, Vietnam.
Thai Minh DienFaculty of Medicine, Nam Can Tho University, Can Tho City, Vietnam.
Trinh Nhut TruongCa Mau Obstetrics and Pediatrics Hospital, Ca Mau City, Vietnam.
Hua Kim ChiCa Mau Obstetrics and Pediatrics Hospital, Ca Mau City, Vietnam.
Bui Kim DangCa Mau Obstetrics and Pediatrics Hospital, Ca Mau City, Vietnam.
Vo Van ThiFaculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To investigate the associations of serum 25-hydroxyvitamin D (25(OH)D) concentrations and vitamin D receptor (VDR) polymorphisms with dengue severity in hospitalized Vietnamese children. Methods: This cross-sectional study included 190 children aged ≤16 years with laboratory-confirmed dengue admitted to Ca Mau Obstetrics and Pediatrics Hospital, Vietnam. Disease severity was classified according to the World Health Organization 2009 criteria. Serum 25(OH)D concentrations were measured, and four VDR polymorphisms (FokI, BsmI, ApaI, and TaqI) were genotyped. Associations with severe dengue were assessed using univariable and multivariable logistic regression. Results: Thirty-two children (16.8%) had severe dengue. Median serum 25(OH)D concentrations were lower in children with severe dengue than in those with non-severe dengue (21.26 vs 26.65 ng/mL; Conclusion: Lower serum 25(OH)D concentrations were associated with severe dengue, whereas the investigated VDR polymorphisms were not. Prospective multicenter studies are needed to clarify temporality and causality.

Indexed as

25-Hydroxyvitamin DChildrenDengue severityVDR polymorphismsVietnamVitamin D receptor

Identifiers

PMID42774980
PMCPMC13594944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.