ArticleiScience2026
High-resolution spatial transcriptomics of irradiated submandibular glands treated with fortified fibrin hydrogels.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Previous studies showed that fortified fibrin hydrogel (Ep-FH), generated by conjugating laminin-1 peptides (A99 and YIGSR) and growth factors (FGF7 and FGF10) to fibrin hydrogels, improves epithelial organization and secretory function in irradiated mouse submandibular glands (SMG). To define the cell type-specific mechanisms underlying these effects, we generated high-resolution spatial transcriptomic profiles using the Xenium Prime Mouse Pan Tissue and Pathways Panel (5,000 genes). Treatment with Ep-FH partially reactivated secretory- and polarity-related genes, shifted stromal and immune transcriptional programs toward the non-irradiated state, and reduced profibrotic signaling. Integrative clustering further showed increased similarity of acinar, stromal, immune, and myoepithelial populations to non-irradiated controls, whereas ductal, endothelial, and glial cells showed limited responses. These findings indicate that Ep-FH partially restores transcriptional programs in selected cell populations, suggesting that further optimization may improve regeneration throughout the irradiated SMG.
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