Evidence map›Paper›PMID 42774900›Full record

ArticleMaterials today. Bio2026

Bioorthogonal aggregation-induced emission nanoprobes for targeted photodynamic eradication of Gram-negative pathogens in periodontitis.

Shisheng Cao, Cailing Zhao, Surong Guo, Jiashen Hu, Qing Yang, Xin Li, Yiping Liu, Dan Ding, Huijuan Yin, Juan Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shisheng CaoTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin, 300070, PR China.
Cailing ZhaoTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin, 300070, PR China.
Surong GuoTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin, 300070, PR China.
Jiashen HuInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, 300192, PR China.
Qing YangTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin, 300070, PR China.
Xin LiTianjin Medical University Institute of Stomatology, No.12 Qixiangtai Road, Heping District, Tianjin, 300070, PR China.
Yiping LiuTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin, 300070, PR China.
Dan DingSchool of Materials Science and Engineering, Smart Sensing Interdisciplinary Science Center, Nankai University, Tianjin, 300350, PR China.
Huijuan YinInstitute of Biomedical Engineering, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, 300192, PR China.
Juan ZhangTianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin, 300070, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is a bacteria-driven immune-inflammatory disease associated with progressive periodontal tissue destruction and alveolar bone loss. Conventional treatments rely heavily on broad-spectrum antibiotics, which can promote antimicrobial resistance and disrupt the oral microbiota. Herein, we report a bioorthogonal aggregation-induced emission (AIE)-based nanoprobe, AIE@PEG-DBCO, designed for the selective imaging and photodynamic elimination of Gram-negative periodontal pathogens. By exploiting the metabolic incorporation of 8-azido-3,8-dideoxy-D-manno-octulosonic acid (KDO-N

Indexed as

Aggregation-induced emissionBioorthogonal chemistryOral microbiota compatibilityPeriodontitisPhotodynamic therapy

Identifiers

PMID42774900
PMCPMC13594721

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.