Evidence map›Paper›PMID 42774886›Full record

ArticleiScience2026

PP2A and CDK16 antagonistically regulate WIPI2B phosphorylation and neuronal autophagosome biogenesis.

Heather Tsong, M Neal Waxham, Andrea K H Stavoe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Heather TsongDepartment of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, TX, USA.
M Neal WaxhamDepartment of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, TX, USA.
Andrea K H StavoeDepartment of Neurobiology and Anatomy, University of Texas Health Science Center at Houston, Houston, TX, USA.

Funding

Autophagy in aging and neurodegenerationR00NS109286 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI STAVOE, ANDREA · 2021 to 2023
$747k
WIPI2B/ATG-18 phosphorylation regulates neuronal autophagosome biogenesis in vivoF31AG086033 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Heather Tsong · 2024 to 2026
$75k
NIA NIH HHS F31 AG086033NINDS NIH HHS R00 NS109286
6 · The paper itself

Abstract

Autophagy is a homeostatic mechanism for recycling cellular constituents. In primary murine neurons, autophagosome biogenesis declines during aging. Importantly, this decline can be restored by the ectopic expression of key autophagy component WIPI2B. The phosphorylation state of WIPI2B serine 395 is critical for this restoration, suggesting that WIPI2B S395 phosphorylation regulates autophagosome biogenesis. Here, we identified protein phosphatase 2A (PP2A) and CDK16 as regulators of WIPI2B S395 phosphorylation and neuronal autophagy. Using

Indexed as

autophagyC. elegansneuronphosphorylation

Identifiers

PMID42774886
PMCPMC13594722

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.