Evidence map›Paper›PMID 42774868›Full record

ArticleiScience2026

Transcriptomic characterization of transitional B cells reveals four subsets with perturbed activation profiles in scleroderma.

Claire Beesley, Nina Goldman, Gisela Gabernet, Edel Aron, Cankut Çubuk, Myles J Lewis, Louisa K James, Gur Yaari, Steven H Kleinstein, David J Abraham and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Claire BeesleyDivision of Medicine, Centre for Rheumatology, University College London, London, UK.
Nina GoldmanDivision of Medicine, Centre for Rheumatology, University College London, London, UK.
Gisela GabernetDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
Edel AronDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
Cankut ÇubukCentre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Myles J LewisCentre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Louisa K JamesCentre for Immunobiology and Infection, Faculty of Medicine and Dentistry, Blizard Institute, Queen Mary University of London, London, UK.
Gur YaariDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
Steven H KleinsteinDepartment of Pathology, Yale School of Medicine, New Haven, CT 06520, USA.
David J AbrahamDivision of Medicine, Centre for Rheumatology, University College London, London, UK.
Christopher P DentonDivision of Medicine, Centre for Rheumatology, University College London, London, UK.
Rizgar A MageedDivision of Medicine, Centre for Rheumatology, University College London, London, UK.
Voon OngDivision of Medicine, Centre for Rheumatology, University College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We previously demonstrated that patients with scleroderma or systemic sclerosis (SSc) have elevated autoreactive transitional B cells, including against topoisomerase I (anti-topoisomerase I autoantibody [ATA

Indexed as

autoimmunityB cellssystemic sclerosis

Identifiers

PMID42774868
PMCPMC13594708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.