Evidence map›Paper›PMID 42774867›Full record

ArticleAggression and violent behavior

Targeting Serotonin 5-HT

Simona Scheggi, Giulia Braccagni, Caterina Branca, Marco Bortolato

Abstract read
In one paragraph

Article in Aggression and violent behavior. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simona ScheggiDepartment of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Giulia BraccagniDepartment of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Caterina BrancaDepartment of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Marco BortolatoDepartment of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL, USA.

Funding

Deciphering gene-environment interactions in pathological reactive aggressionR01MH104603 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Marco Bortolato, Regina A. Mangieri · 2014 to 2026
$6.0M
Disentangling the biological links between violence and alcohol useR01AA030256 · NIAAA · UNIVERSITY OF UTAH · PI Marco Bortolato, Regina A. Mangieri · 2023 to 2026
$2.2M
NIAAA NIH HHS R01 AA030256NIMH NIH HHS R01 MH104603
6 · The paper itself

Abstract

Aggression, anger, and irritability emerge from dysregulated interactions between prefrontal and limbic circuits, with serotonin (5-HT) exerting a central regulatory influence. Among serotonergic targets, the 5-HT

Indexed as

5-HT2A receptoraggressionantipsychoticspsychedelicsserotonin

Identifiers

PMID42774867
PMCPMC13595866

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.