Evidence map›Paper›PMID 42774788›Full record

ArticleAesthetic surgery journal. Open forum2026

New Proposal in the Approach to Brachial Remodeling: The Melfa-Anastasia Arm Laxity System (MAALS).

Melfa Fabrizio, Anastasia Dafne, Ciranna Gabriele, Melfa Sonia, Nicoletti Giovanni

Abstract read
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Article in Aesthetic surgery journal. Open forum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Melfa FabrizioSurgery and Aesthetic Medicine, Mediaging Clinic Center, Palermo and Milan, Italy.ORCID https://orcid.org/0000-0002-1009-0527
Anastasia DafneSurgery and Aesthetic Medicine, Mediaging Clinic Center, Palermo and Milan, Italy.ORCID https://orcid.org/0009-0000-4264-593X
Ciranna GabrieleSurgery and Aesthetic Medicine, Mediaging Clinic Center, Palermo and Milan, Italy.ORCID https://orcid.org/0009-0002-8794-2502
Melfa SoniaSurgery and Aesthetic Medicine, Mediaging Clinic Center, Palermo and Milan, Italy.ORCID https://orcid.org/0009-0006-5895-0545
Nicoletti GiovanniInterdepartmental Research Centre for Technologies Applied to Regenerative Medicine and Inductive Surgery (T.A.Me.Ri.C.I.), University of Pavia, Pavia, Italy.ORCID https://orcid.org/0000-0002-1507-4067

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Current diagnostic tools for upper arm laxity assessment-including the pinch test and two-dimensional photographic scales-fail to characterize the underlying tissue composition, leading to inappropriate treatment selection and preventable complications. Objectives: To introduce the Melfa-Anastasia Arm Laxity System (MAALS), a precision medicine framework integrating high-frequency ultrasound (HFUS) biometry with a cylindrical geometric model for objective, compositional assessment of brachial architecture. Methods: MAALS employs a noncontact stand-off technique (HFUS, 18-22 MHz) to measure superficial adipose tissue thickness (SAT) and triceps muscle thickness (M) at the mid-brachial sentinel point. Two dimensionless indices are derived: the adipose saturation percentage (%SAT = SAT/Rtot × 100) and the muscle filling ratio (MFR = M/Rtot), where Rtot is the total brachial radius calculated from arm circumference. Results: Based on preliminary anatomically rational thresholds, MAALS defines five phenotypes (0-4): normotrophic (0), adipose hypertrophy (1), mixed morphology (2), pure cutaneous ptosis with critical vascular risk zone (%SAT < 20%, SAT < 4-5 mm; liposuction contraindicated) (3), and sarcopenic/atrophic (4). Each phenotype carries specific therapeutic indications ranging from prevention to regenerative strategies. Conclusions: MAALS is presented as a conceptual precision medicine framework requiring prospective validation, not as an established clinical standard. By providing objective compositional characterization of brachial architecture, it offers a structured basis for safer, more individualized treatment planning, future multicenter validation studies, and integration with AI-based segmentation technologies. Level of Evidence 5 Therapeutic:

Identifiers

PMID42774788
PMCPMC13594674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.