Evidence map›Paper›PMID 42774653›Full record

ArticleiScience2026

Type I IFN dynamics orchestrate protective ICAM1

Riho Saito, Yuan Ding, Kureha Satou, Fumi Yamamoto, Akisawa Satomi, Hiroki Sugishita, Hideki Ukai, Yukiko Gotoh, Tomohiko Okazaki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Riho SaitoInstitute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan.
Yuan DingInstitute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan.
Kureha SatouInstitute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan.
Fumi YamamotoInstitute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan.
Akisawa SatomiLaboratory of Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Hiroki SugishitaLaboratory of Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Hideki UkaiES-mouse/Virus Core, International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo 113-0033, Japan.
Yukiko GotohLaboratory of Molecular Biology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Tomohiko OkazakiInstitute for Genetic Medicine, Hokkaido University, Sapporo, Hokkaido 060-0815, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early host response influences outcomes following viral infection. Here, we leveraged variability in survival after intranasal vesicular stomatitis virus (VSV) challenge in genetically identical mice to retrospectively profile systemic immune responses associated with survival or lethality. Survival was strongly associated with a robust systemic type I interferon (IFN) surge within 24 h of infection, and blockade of type I IFN signaling during this narrow early window markedly reduced survival, establishing early IFN induction as a key determinant of outcome. This protective IFN surge rapidly remodeled the systemic immune landscape, inducing a specialized ICAM1

Indexed as

innate immunityneutrophiltype I IFNviral infectionVSV

Identifiers

PMID42774653
PMCPMC13594436

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.