Evidence map›Paper›PMID 42774621›Full record

ArticleiScience2026

Vagal nerve stimulation induces vascular oscillations and enhances long-term learning.

Junyu U Chen, Yoko Ikoma, Ko Matsui

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Junyu U ChenSuper-network Brain Physiology, Graduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.
Yoko IkomaSuper-network Brain Physiology, Graduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.
Ko MatsuiSuper-network Brain Physiology, Graduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite its rapid emergence as a powerful approach for probing peripheral modulation of brain function, vagus nerve stimulation (VNS) is primarily understood through neuromodulatory pathways, leaving the potential contribution of vascular dynamics largely unexplored. Here, we examined whether VNS influences learning performance and its relationship with cerebrovascular dynamics using a chronic cuff-electrode system in freely moving mice. Using a cerebellum-dependent horizontal optokinetic response (HOKR) paradigm, we show that post-training VNS selectively enhances long-term learning. In parallel,

Indexed as

brain metabolismHOKRhorizontal optokinetic responseslearning and memoryvagus nerve stimulationvascular dynamics

Identifiers

PMID42774621
PMCPMC13594465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.