Evidence map›Paper›PMID 42774613›Full record

ArticleJournal of arrhythmia2026

Glucagon-Like Peptide-1 Agonists and the Incidence of Atrial Fibrillation in Obese Patients With Heart Failure With Preserved Ejection Fraction and No Diabetes.

Farah Rassam, Esteban Kosak Lopez, Sarah Sass, Thitiphan Srikulmontri, Evan Isaacs, John Malin, Phuuwadith Wattanachayakul, Olayinka Afolabi-Brown

Abstract read
In one paragraph

Article in Journal of arrhythmia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Farah RassamMedicine Department Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA.ORCID https://orcid.org/0009-0000-2909-562X
Esteban Kosak LopezMedicine Department Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA.ORCID https://orcid.org/0009-0004-6831-9912
Sarah SassMedicine Department Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA.
Thitiphan SrikulmontriMedicine Department Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA.ORCID https://orcid.org/0009-0009-6672-649X
Evan IsaacsMedicine Department Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA.ORCID https://orcid.org/0009-0006-8494-1765
John MalinMedicine Department Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA.
Phuuwadith WattanachayakulMedicine Department Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA.ORCID https://orcid.org/0000-0003-0086-5269
Olayinka Afolabi-BrownCardiology Department Jefferson Einstein Philadelphia Hospital Philadelphia Pennsylvania USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) reduce cardiovascular risk in obesity, but their effect on atrial fibrillation (AF) in heart failure with preserved ejection fraction (HFpEF) remains unclear. Methods: We analyzed TriNetX data comparing obese, non-diabetic HFpEF patients treated with GLP-1 RAs ( Results: GLP-1 RA therapy was not associated with reduced AF incidence (HR 0.86; 95% CI, 0.53-1.39; Conclusions: GLP-1 RAs may not reduce AF incidence in obese, HFpEF patients.

Indexed as

atrial fibrillationdiabetes mellitusglucagon‐like peptide‐1 receptor agonistsheart failure with preserved ejection fractionobesity

Identifiers

PMID42774613
PMCPMC13595020

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.