ArticleEClinicalMedicine2026
Treatment and outcome of chronic disseminated candidiasis in the era of antifungal prophylaxis: a retrospective multicentre cohort of 111 patients.
Article in EClinicalMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01731353 (FungiScope - A Global Emerging Fungal Infection Registry), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
FungiScope - A Global Emerging Fungal Infection Registry
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
53 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic disseminated candidiasis (CDC) is a severe manifestation of invasive candidiasis predominantly affecting patients with haematological malignancies. Treatment recommendations are based on limited observational data, and the impact of widespread antifungal prophylaxis on CDC epidemiology and outcomes remains poorly characterised. We aimed to comprehensively characterise CDC and explore associations between antifungal treatment strategies and clinical outcomes. Methods: We performed a retrospective, multinational cohort study including adults with possible, probable, or proven CDC diagnosed between 2007 and 2025 identified through the FungiScope® registry (ClinicalTrials.gov: NCT01731353) and collaborating networks in 19 countries. Diagnostic findings, treatment strategies, and outcomes were analysed over 12 months. Exploratory comparative analyses assessed the association between antifungal treatment strategies and treatment response (composite of clinical, radiological, and mycological findings) and overall survival using inverse probability of treatment weighting to account for the time-varying confounders neutropenia and corticosteroid exposure. Findings: Of 111 patients, CDC was classified as possible in 23.4% (n = 26), probable in 50.5% (n = 56), and proven in 26.1% (n = 29) of patients. The predominant species were Interpretation: No statistically significant associations between antifungal treatment strategy and treatment response or survival were detected in this retrospective dataset. However, the comparative treatment analyses were exploratory and the study was not powered to exclude clinically meaningful differences between antifungal strategies. Median treatment duration was shorter than previously reported. Future prospective studies integrating immunological biomarkers and the use of PET/CT-guided strategies are needed to optimise individualised treatment decision-making. Funding: This study received no dedicated external funding. FungiScope® receives unrestricted grants for registry maintenance and infrastructure from Basilea Pharmaceutica, Melinta Therapeutics LLC, Mundipharma Ltd., and Pfizer Inc, which had no role in the study design, conduct analysis, interpretation, manuscript preparation, or the decision to submit for publication.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.