Evidence map›Paper›PMID 42774534›Full record

ArticleResuscitation plus2026

Effects of systemic mild hypercapnia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation.

Anthony Moreau, Fuhong Su, Lorenzo Ferlini, Nicolas Gaspard, Francesca Pischiutta, Elisa Zanier, Jacques Creteur, Filippo Annoni, Fabio Silvio Taccone

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Anthony MoreauDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université libre de Bruxelles (ULB), Brussels, Belgium.
Fuhong SuDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université libre de Bruxelles (ULB), Brussels, Belgium.
Lorenzo FerliniDepartment of Neurology, Hôpital Universitaire de Bruxelles (HUB), Université libre de Bruxelles (ULB), Brussels, Belgium.
Nicolas GaspardDepartment of Neurology, Hôpital Universitaire de Bruxelles (HUB), Université libre de Bruxelles (ULB), Brussels, Belgium.
Francesca PischiuttaLaboratory of Traumatic Brain Injury and Neuroprotection, Department of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy.
Elisa ZanierLaboratory of Traumatic Brain Injury and Neuroprotection, Department of Acute Brain and Cardiovascular Injury, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri 2, 20156 Milan, Italy.
Jacques CreteurDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université libre de Bruxelles (ULB), Brussels, Belgium.
Filippo AnnoniDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université libre de Bruxelles (ULB), Brussels, Belgium.
Fabio Silvio TacconeDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université libre de Bruxelles (ULB), Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Cardiac arrest (CA) is a major cause of mortality and neurologic disability. Extracorporeal cardiopulmonary resuscitation (ECPR) may be used in refractory CA to potentially reduce hypoxic-ischemic brain injuries. Currently, no recommendation exists regarding optimal carbon dioxide levels in ECPR patients. Methods: Twelve pigs were submitted to 5 min of untreated ventricular fibrillation followed by 25 min of CPR; 30 min after CA induction, ECPR was initiated and defibrillations delivered until ROSC. Pigs were randomly assigned to normocapnia (NC; PaCO Results: Mean PbtO Conclusions: In this model of ECPR, HC was associated with increased cerebral glucose concentrations and reduced caspase-8 expression, without changes in PbtO

Indexed as

ECPRHypoxic-ischemic brain injuryMultimodal neuromonitoringRefractory cardiac arrestSystemic mild hypercapnia

Identifiers

PMID42774534
PMCPMC13594752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.