Evidence map›Paper›PMID 42774471›Full record

ArticleExploration (Beijing, China)2026

ER-Localized Deadenylase

Lexin Liu, Yuelin Guan, Yuzhou Qin, Guiping Chen, Guozhen Wang, Xiang Yan, Xue Li, Lei Sun, Wei Yu, Shi Ouyang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Exploration (Beijing, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lexin Liu *Department of Urology, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou China.
Yuelin Guan *Department of Urology, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou China.
Yuzhou Qin *Department of Gastrointestinal Surgery, Guangxi Medical University Cancer Hospital Guangxi Clinical Research Center for Colorectal Cancer Nanning, Guangxi Autonomous Region China.
Guiping ChenDepartment of Gastrointestinal Surgery The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China.
Guozhen WangSchool of Basic Medical Sciences and Forensic Medicine Hangzhou Medical College Hangzhou Zhejiang China.
Xiang YanDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou China.
Xue LiDepartment of Big Data in Health Science School of Public Health and The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China.
Lei SunShandong Provincial Key Laboratory of Animal Cell and Developmental Biology School of Life Sciences Shandong University Qingdao China.
Wei YuInstitute of Translational Medicine Zhejiang University School of Medicine Hangzhou China.
Shi OuyangDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou China.
Zhichao MaDepartment of Gastrointestinal Surgery The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China.
Zihao XuDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou China.
Zhongkai CaoDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou China.
Fan YuDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou China.
Tong ZhouShandong Provincial Key Laboratory of Animal Cell and Developmental Biology School of Life Sciences Shandong University Qingdao China.
Ziyou LuoShandong Provincial Key Laboratory of Animal Cell and Developmental Biology School of Life Sciences Shandong University Qingdao China.
Xiangjun ChenInstitute of Translational Medicine Zhejiang University School of Medicine Hangzhou China.
Yongbin YanState Key Laboratory of Biomembrane and Membrane Biotechnology School of Life Science Tsinghua University Beijing China.
Lidan HuDepartment of Urology, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Children and Adolescents' Health and Diseases Hangzhou China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, highlighting the urgent need for novel therapeutic strategies. In this study, we find that PARN-like Domain Containing protein-1 (PNLDC1), an endoplasmic reticulum-localized deadenylase, lower expresses in 91 clinical CRC tissues. Using both in vitro and in vivo models, we identify PNLDC1 as a key tumor suppressor by modulating cell cycle progression in CRC. RNA-immunoprecipitation and sequencing analyses reveal that PNLDC1 binds cell cycle-associated mRNAs, with

Indexed as

colorectal cancerdeadenylasepatient‐derived tumor cell clusterPNLDC1TUBB4B

Identifiers

PMID42774471
PMCPMC13593926

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.